Anti-ageing Dormins

Skin extrinsic ageing

bulbThis is the accumulated damage derived from external assaults. According to Harman’s free radical theory of ageing, organisms age because cells accumulate free radical damage with the passage of time. UV and free radicals induce inflammation and damage cell content such as DNA, the extracellular matrix as well as the cell membranes as well as increasing cell proliferation resulting in premature aging

Preventing oxidative damage may delay premature ageing

Skin intrinsic ageing

This is the natural and programmed ageing in the skin. Based on Hayflick’s Limit Theory of Ageing cells have a limited capacity to replicate and as they advance in replication number, they age. Prof. Hayflick theorized that the human cells ability to divide is limited to approximately 50-times, after which they simply stop dividing and die.

The theory was accommodated with the discovery of the cell internal biological clock - the telomeres.

A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from destruction. Each time the cells replicates the telomeres are shortened. The telomere shortening mechanism normally limits cells to a fixed number of divisions which comes in line with Hyflick’s Limit theory and observations. Studies suggest that this is responsible for ageing on the cellular level and sets a limit on cells lifespan.

Maintenance of telomeres via slow down of cell proliferation may be one way to maintain youth.

2009 Nobel Prize for Medicine was awarded for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase

It is believed that slowing down cell proliferation preserves the cell youth capital, thereby delay the ageing process

Anti-ageing with DORMINs technology

The slowing of cell proliferation can be accomplished via the concept of dormancy. Dormancy is a natural state that plants and some animals enter to protect themselves from unfavourable environmental and growth conditions.

During dormancy cell proliferation and growth is inhibited. Flower bulbs are a good example: they go dormant through the winter season and emerge as beautiful, rejuvenated blossoms in the spring.

Inhibition of cell proliferation during dormancy is achieved through DORMINs. However, the chemical nature of these entities varies between plants and organisms, which is why it has been difficult to determine their mechanism of action beyond reversing growth arrest. Once dormins are removed, cell growth resumes; thus dormins are a favourable approach to treat intrinsic aging since they are reversible cell proliferation inhibitors. Further, it is known3 that UV and oxidative stress can cause enhanced proliferation leading to premature ageing. Therefore, slowing this proliferation process could not only preserve the cell youth capital, but also slow the effects of premature ageing.

DORMINS technology platform and products (a patented technology of IBR Ltd) comes to address intrinsic aging via one of the suggested mechanisms, ie SLOWING DOWN CELL PROLIFERATION TO SLOW DOWN AGING.

The platform includes different products that carry in common the DORMINs mechanism of slowing down ageing, but, differ from each other in there composition and additional benefits.

A Safety Guide to Sunbathing

sunbathingWhether it is hot or cold outside, having a tan can give you a healthy glow that leaves you looking and feeling more attractive. However, in the pursuit of that glow, you should not put yourself at risk. By following some simple safety tips, you can get the tan you want without causing damage.

Avoid Excess UV

One of the biggest temptations tanners face is the accelerated colouring that comes with using a sunbed or foregoing sun cream. As UV rays are one of the biggest causes of cancer, and the primary cause of sunburn, minimising the amount you encounter is important. With regards to sunbeds, you should avoid using them altogether. It is estimated that they emit up to 15 times more UV rays than the sun, which can cause uncomfortable burns and lay the foundations for a skin tumour. When out in the sun, apply a sun cream that is at least factor 15 or above on an hourly basis. You will get a tan eventually, but without posing a large risk to your skin. Ideally, you should not expose yourself to too much sun time in general; not only will this increase your risk of cancer, it will also lead to sunstroke.

Taking Care of Yourself as You Tan

Whether you are sunbathing at home or abroad, you need to take some steps that will maintain your health. If you do not stay hydrated while sunbathing, you will soon find that you become dehydrated. Not only does dehydration make you feel uncomfortable, it can also cause sunstroke, which will cause you to experience flu-like symptoms for up to three days. In addition to this, you should hit the shade between 12 and 3pm. At this time of day, the sun is at its hottest, which means you are at greater risk of burning. Finally, do not underestimate the sun’s ability to damage your eyes; stick on a pair of great looking sunglasses, and you will keep them protected too.

Are Bubble Bath Ingredients Harmful?

Soak yourself in toxic bubbles!

bbTaking a bath is much more than getting yourself clean. To me it’s a ritual, an indulgence, a therapeutic experience, and if I don’t get it, I miss it.

And the manufacturers of the bubble bath products understand this only too well. They know I need to feel pampered and indulged and to have not just my body soothed, but my ego as well. OK, I admit it!

BUT, when you sink into a warm bubble bath full of lovely, smelly bubbles, do you know what’s happening to your skin? The bad news is that it gets worse the longer you stay in the bath.

With some skin care products (like face wash, for example), if there are harmful ingredients, you rinse them off almost immediately. But with a bubble bath, the chances are you stay in the water as long as you can – enough time for any harmful ingredients to really soak into your skin and start causing trouble.

Contact dermatitis is a common reaction that you may notice. Your skin will develop a red, itchy rash which is severely irritating. Further exposure to the chemicals (even in another product) makes it worse. The only safe skin care is to stop using anything but water on your skin.

Check your bubble bath for any of these potentially harmful ingredients:

Sodium laureth sulfate is a high foaming surfactant, which is included in the bubble bath as a cleaning agent. It makes the skin more permeable, enabling other chemicals to penetrate the skin. Sodium laureth sulphate is also potentially harmful because, in the manufacturing process, it can form dioxane as a by-product. Dioxane (1,4-Dioxane) is a known carcinogen, causing cancer in rats and mice. Dioxane is easily absorbed through human skin. Sodiul laureth sulphate can also be an eye irritant.

Cocamidopropyl betaine can cause contact allergies and dermatitis, and can be contaminated with impurities linked to cancer or other significant health problems.
Propylene glycol is a humectant, which means that it is included in the product to stop the product drying out. It alters the structure of the skin, and can inhibit cell growth. It can also carry other chemicals down into the deeper layers of the skin, making it easier for them to reach the bloodstream. Also used as industrial anti-freeze.

Cocamide DEA is currently under investigation as a cancer causing agent. It can be an irritant and can cause contact dermatitis.

Cocamide MEA is known to cause contact allergies and contact dermatitis. It is unsafe for use in products which could be inhaled, and may form carcinogenic compounds called nitrosamines on the skin or in the body after absorption.

Citric acid is used to exfoliate the skin. It can cause skin irritation, bleeding or pain. Not recommended in products for use by children.

Sodium benzoate is included in cosmetics, and also foodstuffs, to act as a preservative. It kills cells that would otherwise infect the product and make it go ‘off’. This ingredient has been implicated in a number of health issues, but most particularly in the case of people and children suffering from asthma.

Sodium lactate is used as an exfoliating agent. It is an alpha-hydroxy acid (AHA). These acids can cause increased sensitivity to sunlight because they remove an outer layer of skin cells. You should rinse thoroughly after using a bubble bath containing lactic acid, and not expose your skin to the sun immediately after using the product. In the US, the cosmetic industry safety panel recommends restrictions on its use.
5-Bromo-5-nitro-1,3-dioxane is toxic and should be rinsed off thoroughly. It must not be used in products that stay in contact with the skin. It may form carcinogenic compounds called nitrosamines on the skin or in the body after absorption

Benzophenone-3 is used as a UV absorber and can be an irritant and cause contact dermatitis and photosensitivity. Subject to limits on the amount that can be included in the finished product.
Coumarin is used in cosmetics as a fragrance, but it is a cancer suspect and is banned for use in food products in the USA. It is also a component ingredient of warfarin (rat poisin).

Ethylparaben , Butylparaben and Isobutylparaben act as preservatives. They kill cells that would otherwise infect the product and make it go ‘off’. These ingredients have been implicated in a number of health issues, but most particularly in the case of people and children suffering from asthma.

Hexylene glycol can be irritating to the eyes.

Lactic acid is used as an exfoliating agent. It is an alpha-hydroxy acid (AHA). These acids can cause increased sensitivity to sunlight because they remove an outer layer of skin cells. You should rinse thoroughly after using a bubble bath containing lactic acid, and not expose your skin to the sun immediately after using the product. In the US, the cosmetic industry safety panel recommends restrictions on its use.

Rosmarinus officinalis is included as a rosemary oil additive. It can be an irritant.

Sodium hydroxide is a harmful irritant and can be corrosive to skin and harmful to eyes. There are restrictions on how much can be used in skin care products. Labels must state ‘Keep out of the reach of children’.

Urea can cause changes in the skin structure, increasing its permeability, thus allowing other chemicals to penetrate the skin.

CI 42090 (FD&C Blue #1) is a blue colourant known to be carcinogenic.

CI 15510 (D&C Orange #4) is an orange colourant which is known to be harmful or irritant to the eyes. In the EU, it is not allowed to be used in products in or near the eyes.

Health Guidelines on Skin Painting Business

face_painting

Several events and special holidays require participants to wear colourful and vibrant images well-painted on their skin. Having said that, this stem of talent has become a viable business for most artists that cater to groups or individuals that line up during festivals and mardi gras. Just for every artist-entrepreneur, take these simple skin safety guidelines before carrying out a rewarding venture.

The Paint

Of the many particular concerns in body painting, choosing suitable paint types is the most prioritised. There are several paint types that claim to be nontoxic or have safety guarantees. Though most skin paints carry these labels, it is always important to apply colourings, chemicals, and glitters that are approved by health agencies. And before applying these products to customers, always inquire their history of paint allergies.

Hygiene

Next critical supplies consideration is the cleanliness of brushes and sponges. With constant usage, these items may accumulate dirt and bacteria. In such case, these items must be properly sanitised through proper heating process. Observing good hygiene also includes avoidance of head lice and spread of skin infections.

Workspace

Next up, map out the work space! With all the repetitive motions, bending, and twisting, artists will surely experience repetitive motion stress. It is for this reason that motion studies have to be done to minimise the impacts of rhythmic movement stress.

Red Tape

Before marketing your great talent in skin painting, always make sure to complete all necessary documents and legally required licenses. Every business has its own industry-specific requirements that have to be acquired, and the body painting business is no exception. If available, body painting entrepreneurs can even get skin-painting insurance. In some countries, there are niche insurance companies that cater to this service, especially targeted for clowns, entertainers and live-statue employees.
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